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These compounds are incompletely absorbed in the small intestine, which means they reach the large intestine where gut bacteria ferment them, producing gas, bloating, and osmotic diarrhea

The rate of discontinuation due to adverse events varied from 5% to 19%, predominantly due to gastrointestinal side effects [17]

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Significant reduction in HbA1c and body weight was observed in semaglutide and liraglutide as compared to placebo