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Whether this immunoregulatory activity underlies the widespread antimicrobial effects of tamoxifen is still unknown

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For example, DHEA(S) concentrations often decrease non-specifically with chronic illness and this may confound studies examining differences in DHEA(S) concentrations in clinical populations, since the lowered hormone concentrations may reflect chronic medical illness, rather than having diagnostic specificity or direct pathophysiologic significance [157]

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