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Because of their intermittent stimulation of the GLP-1R, short-acting GLP-1RAs retain their ability to delay gastric emptying leading to lower postprandial glucose excursions compared with the long-acting GLP-1RAs, which are associated with the development of tolerance (tachyphylaxis) to GLP-1s effect on gastric emptying (10)

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Bibcode:2007JExpB.210.3430C

Quality assessment of methods and evidence The methodological quality of the included meta-analyses was assessed using the AMSTAR 2 tool 59

Blood glucose monitoring, ideally with a continuous glucose monitor, is strongly recommended in this population before implementing any fasting protocol

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