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Ethical Approval No ethics committee approval was needed as this review only summarizes findings from previously conducted studies with human participants or animals

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In the U.S., for example, only 2% of the obese adult population were historically treated with anti-obesity drugs, due to a combination of lack of clarity about the role and value of pharmacotherapies (which were also less effective and sometimes with greater side effects than the recently launched treatments), limited insurance coverage and resulting out-of-pocket costs 12

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