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If you lose more than 23 pounds weekly for sustained periods, you may be in too aggressive a deficit and should increase intake by 100200 calories to protect lean tissue

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However, once dopamine levels drop, cortisol rises again, creating a cycle of craving and guilt

About half of the people who were included in this study had type 2 diabetes, while the other half had no indication of a diabetes diagnosis in their health records and were likely taking these medications off-label for weight management at their doctors discretion

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