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Winfrey did take a break from the medication early in 2024, she said, and started to regain weight despite continuing to work out and eat healthy foods

If the idea of injecting yourself creates anxiety, that does not mean you are weak or being dramatic

Furthermore, recent studies have demonstrated that GLP-1RAs may exert their anorexigenic effects not only by acting on ARC POMC neurons but also in other brain regions, such as the dorsomedial hypothalamus (DMH) and the dorsal vagal complex in the hindbrain [8, 9]

Besides, GLP-1 can also be produced by neurons in CNS (20, 93)
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