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If the SOUL study corroborates the findings of this model, it may not only form the basis for the calculation of power but also define the duration of such studies, reducing costs and easing the process of designing cardiovascular outcome trials (CVOTs)
It looks like we might be able to add prediabetes and hypertension to the growing list of conditions that Eli Lillys weight loss drug tirzepatide is able to treat, after new analysis of the SURMOUNT-1 trial showed significant reductions in blood pressure and diabetes progression.
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Increasing hydration is easy, drink approximately 1 ounce of water per day per pound of body weight
PS: I would love to hear your thoughts on whether data from medical toxicology and poison centers could be beneficial in generating hypotheses for target identification in drug discovery
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