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The SUPRPASS-4 trial (262), involving 2002 participants with high-risk cardiovascular profiles followed for up to 104 weeks, showed no difference in 4-MACE events (cardiovascular death, myocardial infarction, stroke, and hospitalization for unstable angina) with tirzepatide compared to insulin glargine (HR 0.74
2009;297:E1358E1365
Be sure you eat adequate amounts of protein throughout the day, not just at one meal
Most people find injections quick and relatively painless after the first few times
Long-term Sustainability One of the key advantages of GLP-1 medications is their potential for long-term weight management
Gerstein HC, Colhoun HM, Dagenais GRet al
