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These agents are also associated with a minimal risk of hypoglycemia when used as monotherapy or as add-on to metformin monotherapy, but they can contribute to hypoglycemia when used in combination with medications associated with hypoglycemia, such as insulin and insulin secretagogues

Nature 560 (7719), 499503

The study population was identified in the Danish Civil Registration system using the unique personal identification number (CPR), ensuring precise linkage of recorded individual-level information across registers [21]

Recent findings from studies on humans and animals demonstrate that GLP-1R agonists can also modulate the stress response via HPA axis activation but data obtained so far are ambiguous

[43] This increases the drug's binding to blood protein (albumin), which enables longer presence in the blood circulation

The agency has asked Novo Nordisk to list NAION as a side effect with a frequency of very rare in the product information that comes with the drugs