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Semaglutide and other GLP-1 receptor agonists have demonstrated effectiveness in clinical trials for adolescent weight loss, yet regulatory approval in children remains restricted to specific age groups

Prescriptions made for GLP-1 agonists under various brand names (e.g., Ozempic, Wegovy) have more than tripled since 2020

Identification of genetic variants associated with the efficacy and side effects of GLP1 medications could underpin development of precision medicine approaches in the treatment of obesity.