glp 1 agonists mechanism of action GLP-1 and Anesthesia: Considerations and Cautions for CRNAs Evolution of GLP‐1 Receptor Agonists

Censani M, Chin VL, Fennoy I

Many reports showed that GLP-1 effects involve neural modulation and peripheral effects, which increase satiety, resting energy expenditure and lower plasma concentrations of free fatty acids [20]-[22]

These pharmacokinetic parameters support twice-daily administration in humans

[DOI] [PubMed] [Google Scholar] 40.Pratley R.E., Nauck M.A., Barnett A.H., Feinglos M.N., Ovalle F., Harman-Boehm I

A lower EC 50 indicates a higher peptide potency, or ability to agonise receptor signalling

Short-chain fatty acids (SCFAs) produced by gut bacteria through activation of the G protein-coupled free fatty acid receptors FFAR2 (GPR43) and FFAR3 (GPR41) induce GLP-1 Secretion [159]