how do you switch from semaglutide to tirzepatide Wondering what the dosage conversion is for tirzepatide? Dr Weiss looks at the SURPASS 2 trial to provide a guide. #joinfridays #wegovy #zepbound switching to semaglutide from tirzepatide

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GLP-1 medications like tirzepatide drive rapid weight loss, but muscle tissue can decline alongside fat

vitamin D intake ~20% of recommendations Lean mass risk: protein + calcium insufficiency may contribute, alongside other drivers B-vitamins: thiamine and cobalamin deficits appear to increase over time Clinical takeaway (my approach): GLP-1s dont cause malnutrition in everyone but they can unmask risk in the wrong context (older adults, low-protein diets, restrictive eating patterns, prolonged nausea/vomiting, rapid weight loss, post-bariatric patients)

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The estimated treatment differences (ETDs [95% CIs]) for oral semaglutide 3 mg, 7 mg and 14 mg vs placebo were 11 (13, 9) mmol/mol, 16 (18, 13) mmol/mol and 17 (19, 15) mmol/mol, respectively