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doi: 10.1152/ajpendo.00429.2014 70 GutzwillerJPTschoppSBockAZehnderCEHuberARKreyenbuehlMet al
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Diabetes mellitus is a chronic disease in which the cells of the pancreas produce little insulin (type 1 diabetes) or the body's tissues cannot use it adequately (type 2 diabetes)
The first GLP-1 RAs is exenatide, which was approved by the FDA for the treatment of T2DM in 2005
Even minor compliance deficiencies may create larger concerns if they reveal broader operational weaknesses within a clinics GLP-1 program
Therefore, no dosage adjustment is usually recommended when gliptins are combined with other pharmacological agents
