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One crucial observation made in the early clinical trials with GLP-1RA was that treated patients consistently lost weight relative to controls receiving placebo

With regards to neurodegenerative diseases such as AD and PD, the literature has demonstrated the inhibitory effects of GLP-1 on pro-inflammatory cytokines such as TNF-alpha and IL-1betatwo notorious small molecules identified in the microglial-mediated injury observed in said diseases processes

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Molecular and Cellular Endocrinology, 515 , Article 110921
