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If they persist, patients should consult their providers for prompt action

Lancet 368(9548):16961705 Muskiet MHA, Tonneijck L, Smits MM, Van Baar MJB, Kramer MHH, Hoorn EJ et al (2017) GLP-1 and the kidney: From physiology to pharmacology and outcomes in diabetes

Acta Neuropathol 87:343348

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For 2,000 years, weve been redefining inflammation

These changes often include: More visible cellulite Looser or deflated appearance of the thighs Reduced volume in the legs Skin that appears uneven or creased Areas where fat loss unmasks existing skin quality issues These changes are common and rooted in predictable physiology, not a sign of something wrong. Understanding why they happen can help you make informed, empowered decisions about your body and your options