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The Summary of Product Characteristics (SmPC) approved by the MHRA and EMA does not list decreased or increased libido as a recognised side effect of Saxenda

Thanks to alterations in the food reward pathway, they are supposed to decrease food cravings, preference for energy-dense foods and also prevent overeating [91]

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I am not aware of any berberine trial comparable to LEADER or SELECT: large, multicenter, multi-year, and designed to test cardiovascular or mortality outcomes

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Serious adverse events with tirzepatide are rare but include pancreatitis, gallbladder problems, and potential thyroid concerns (based on animal studies)