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Therefore, the current evidence is more appropriately interpreted as suggesting a possible conception-window benefit after metabolic optimization, rather than confirming a reproducible treatment effect on hard reproductive outcomes (111, 112, 124)

This distinction matters because it means existing contamination still poses a risk

This section covers timing, dosing, what to expect, and how to manage the transition period

injections of 100 nmol kg 1 MK-801 ( n = 7 mice and n = 4 cages), 100 nmol kg 1 GLP-1 ( n = 6 mice and n = 3 cages), 100 nmol kg 1 , GLP-1MK-801 ( n = 6 mice and n = 3 cages), co-administration of 100 nmol kg 1 GLP-1 and 100 nmol kg 1 MK-801 ( n = 6 mice and n = 3 cages) or vehicle (isotonic saline, n = 7 mice and n = 4 cages) for 14 days

And when semaglutide loses patent protection in 2026, generic entry is widely expected to reset access at scale

The role of insulin resistance and diabetes in nonalcoholic fatty liver disease