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Their ability to preferentially reduce fat mass while preserving lean mass is particularly valuable in older adults or those with mobility limitations, for whom muscle loss can have serious health consequences

But because GLP-1 medicationsincluding semaglutide (Ozempic and Wegovy) and tirzepatide (Mounjaro and Zepbound)are relatively new and research is ongoing, experts advise against using them during pregnancy

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Despite these potential anti-inflammatory mechanisms, molecular imaging studies have yielded discrepant results about whether GLP-1 RAs can attenuate vascular wall inflammation

5 Tirzapetide (Mounjaro): 85% of study participants lost at least 5% body weight

[DOI] [PubMed] [Google Scholar] 115.McGlone E.R., Ansell T.B., Dunsterville C., Song W., Carling D., Tomas A., Bloom S.R., Sansom M.S.P., Tan T., Jones B