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The review question, eligibility criteria, prespecified outcomes, riskofbias framework, certaintyofevidence approach, and decision not to perform quantitative pooling in the presence of marked clinical and methodological heterogeneity were defined prospectively and documented in the review protocol

Wang H, Fu Y, Mao J, Jiang H, Du S, Liu P, Tao J, Zhang L, Zhu J

Alghamdi MA, Fallica AN, Virz N, Kesharwani P, Pittal V, Greish K (2022) The promise of nanotechnology in personalized medicine

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The funnel plot showed a symmetrical distribution, indicating no publication bias, supported by Eggers test (p = 0.16) and Beggs test (p = 0.73), with no imputed studies found using the trim and fill model