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A retrospective analysis of tens of thousands of patients with type 2 diabetes (including pooled data from three randomized, double-blind trials), published in the journal Alzheimer's & Dementia in 2022, showed that the incidence of dementia was significantly lower in those with diabetes who had used GLP-1 receptor agonists than in controls (HR: 0.47, 95% CI: 0.25-0.86)

This was a single-arm multicenter prospective study

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Potential long-term brain benefits are under study: Early research hints that GLP-1 drugs may help protect against conditions like Alzheimers or Parkinsons , but these effects are still mostly seen in observational studies, and clinical trials are needed to confirm these links