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If the female rejects his advances, she will bite him and chase him away

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The Phase 2 trial published in NEJM enrolled 338 adults with obesity (BMI 30) or overweight with comorbidities (BMI 27 plus at least one weight-related condition)

Therefore, future studies are needed to elucidate the weight loss-dependent and -independent mechanisms of benefit in obese HFpEF treatment, utilizing both preclinical and clinical investigations