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Drop back by at least one escalation step and work up again

The Bridge is specifically for patients whose only clinical indication for a GLP-1 is obesity

It also succeeds the now-defunct Qwo, which used injected bacterial enzymes to dissolve the bands under the skin and was taken off the market after less than two years because it caused intense bruising and had the potential for long-lingering skin discoloration from iron-containing pigment left over from ruptured red blood cells (called hemosiderin staining)

When this lipid burden is accompanied by lipotoxicity, oxidative stress, mitochondrial dysfunction, and inflammatory signaling, simple steatosis can progress to metabolic dysfunctionassociated steatohepatitis (MASH), then to fibrosis and, in a subset, cirrhosis
