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Although clinical trials can provide powerful evidence to evaluate the efficacy of novel drugs, their ability to draw definitive conclusions about drug safety is limited due to the finite scope, restricted time frame, strict study entry criteria, and relatively small sample sizes

The science behind this is fascinating

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Diabetic Retinopathy Progression Some clinical trials have reported worsening diabetic retinopathy in patients using semaglutide, especially among those with long-standing diabetes, elevated baseline A1C levels, or concurrent insulin therapy

, where the authors did not report significant differences in the incidence of adverse events between the placebo group and the D-allulose groups (Reference Tanaka, Kanasak and Hayashi41)