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glp-1 discontinuation weight regain Trajectory of the body after drug in the treatment of anti-obesity medications | BMC Medicine November Blog - What happens
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While these werent direct head-to-head trials (different studies, different populations), the magnitude of difference is striking
Phase 3 trial data has now demonstrated weight loss outcomes that, in some patient groups, approach those previously only achieved through bariatric surgery

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In a public advisory on Wednesday, Health Canada said that as interest grows in GLP-1 products for weight loss, "some people may turn to unauthorized or counterfeit products, which could pose serious health risks because they have not been assessed by Health Canada for safety, effectiveness, or quality." The versions of the medications authorized for use in Canada are semaglutide (Ozempic and Wegovy injections and Rybelsus oral tablets) and tirzepatide (Mounjaro and Zepbound injections)

Faillie JL, Yin H, Yu OHY, et al