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Notable Articles of 2024: FLOW trial In patients with type 2 diabetes and chronic kidney disease, weekly semaglutide significantly reduced risks of major kidney events, cardiovascular events, and death from any cause while slowing loss of kidney function.

Aspirin (Acetylsalicylic Acid) Mechanism: Irreversibly inhibits COX-1 enzyme thromboxane A inhibits platelet aggregation Indications: Acute coronary syndrome (ACS) Myocardial infarction (primary & secondary prevention) Stroke/TIA prevention Peripheral arterial disease Dose: Low-dose: 75100 mg/day for antiplatelet effect Higher doses: anti-inflammatory (not usually for antiplatelet) Side Effects: Gastrointestinal irritation / bleeding Allergic reactions Rare: Reyes syndrome (in children) Clopidogrel Mechanism: Irreversibly inhibits ADP (P2Y12) receptor on platelets prevents platelet activation and aggregation Indications: ACS (with or without stenting) Post-percutaneous coronary intervention (PCI) with stent Stroke/TIA prevention Peripheral arterial disease Dose: 75 mg orally once daily (after a loading dose in ACS: 300600 mg) Side Effects: Bleeding (less GI irritation than aspirin) Rare: thrombotic thrombocytopenic purpura (TTP)

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adults met eligibility criteria for oral semaglutide