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Standard management includes eating smaller meals, avoiding fatty or fried foods, staying hydrated, and taking acid reflux medication if needed

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Documented antitumor mechanisms include suppression of excessive inflammation and potential functional restoration of CD8+ T cells, reduction of NET formation in neutrophils to enhance CD8+ T cell cytotoxicity, direct restoration of NK cell function with indirect promotion of N1-polarized neutrophils, and promotion of DC maturation and antigen presentation to reinforce T-cell activation

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Other important contributing factors are eating disorders and depression, which are more common in patients with T1D compared to the overall population ( Figure 1 Obesity increases the risk of obesity-related as well as diabetes-related complications in patients with T1D, including micro- and macrovascular complications, various types of cancer, and overall mortality ( Figure 1 )

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