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Chen, L

In an additional, 30-week placebo-controlled, study of patients with type 2 diabetes inadequately controlled with metformin comparing the maintenance of sitagliptin 100 mg versus withdrawal of sitagliptin when initiating basal insulin therapy, the event rate and incidence of documented symptomatic hypoglycemia (blood glucose measurement 70 mg/dL) did not differ between the sitagliptin and placebo groups

OA The stiffness generally loosens up within 30 minutes, notes the NIHAMD

However, these findings remain preliminary, inconsistent across studies, and have not been robustly demonstrated in well-designed human clinical trials

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