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& Phelan, S

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This guide is about nutrition, not medical advice

The beneficial effects of a Paleolithic diet on type 2 diabetes and other risk factors for cardiovascular disease

Several of the downregulated proteins are centrally implicated in cardiovascular and metabolic pathologies: TNFRSF11B (Osteoprotegerin) has been consistently associated with coronary artery calcification and vascular dysfunction and is known to be upregulated in human vascular smooth muscle cells predisposed to senescence and atherogenesis 6466