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GLP-1 agonists slow gastric emptying and reduce thirst signalling, which can lead to mild chronic dehydration in patients who don't consciously increase fluid intake

Side effects are generally similar for both forms, primarily involving gastrointestinal symptoms like nausea that often improve over time

An in vitro experiment demonstrated that GLP-1RA induces the phosphorylation of Akt, PDK-1, and PKC-, which are key proteins involved in the insulin signaling pathway

It can affect focus, mood, confidence, meal choices, and the ability to feel calm around food

Doi: 18

Participants showed significant reductions in fatigue, improvements in feelings of liveliness, and enhanced cognitive performance measured by psychomotor vigilance testing