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Early Time-Restricted Feeding Improves Insulin Sensitivity, Blood Pressure, and Oxidative Stress Even without Weight Loss in Men with Prediabetes (Sutton et al.) Cell Metabolism (Cell Press) 2018 Landmark RCT supporting the claim that time-restricted eating may improve insulin sensitivity and blood sugar 'particularly when the eating window sits earlier in the day,' independent of weight loss

The study did not find similar optic nerve risks with drugs such as Mounjaro or Zepbound, which use a different mechanism

However, in mice without the GLP-1 receptor, D-allulose had no effect

This article is for information only and is not a substitute for medical advice

The FDA has repeatedly emphasized the necessity of patients only obtaining weight-loss drugs with a prescription from a licensed healthcare provider, and then only from state-licensed pharmacies or outsourcing facilities registered with FDA

Extended-release formulations (650 mg) can be taken every 8 hours