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As for the effects of chronic fat intake on GIP secretion, the expression of regulatory factor X 6 (Rfx6) and pancreatic and duodenal homeobox 1 (Pdx1), important transcription factors involved in GIP expression [67-69], was found to be increased in GIP-producing cells in high-fat diet (HFD)-induced obese mice, suggesting a possible mechanism for GIP hypersecretion in obesity [68, 70]

According to FDA prescribing information, fatigue occurs in approximately 11% of patients taking Wegovy and 5-9% of patients taking Saxenda

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Multiple metabolic benefits of mazdutide in supporting weight management GCG receptors are mainly expressed in the liver, and GCG receptor agonism can inhibit hepatic fat synthesis and promote hepatic lipolysis

More importantly, the human studies that now exist directly contradict the animal findings

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