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When substantial fat loss occurs, circulating estrogen levels may fluctuate, temporarily disrupting the delicate hormonal balance required for regular ovulation and menstruation

Some experts feel that the increase in relative risk for venous thromboembolism conferred by tamoxifen for breast cancer prophylaxis does not differ much from that seen with oral contraceptives or hormone replacement therapy

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This is especially crucial when using semaglutide, as it suppresses your appetite

Evidence suggests that more than 18,000 illegal weight-loss medicines were seized at UK borders between 2024 and mid-2025