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These include orlistat (available on prescription or over the counter as Alli) and, more recently, semaglutide (Wegovy), which is recommended by NICE TA875 for use via NHS specialist weight management services in adults meeting defined BMI and comorbidity criteria

Cancer-associated fibroblasts Cancer-associated fibroblasts (CAFs) constitute the main cell type in the tumour stroma

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These criteria aim to (a) ensure that the prescription is for PD, (b) the patient is not receiving the medication as part of an evaluation or receiving a single 90-day fill, and (c) identify the true starting point of treatment as opposed to evaluation

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