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Description
Since the number of available contrasts for the non-hypothesized direction is too low, we will focus in the meta-analysis on the hypothesized direction for ghrelin and GLP-1

Glucagon-like peptide-1 infusion must be maintained for 24 hours/day to obtain acceptable glycemia in type 2 diabetic patients who are poorly controlled on sulphonylurea treatment

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Notably, metformin can directly upregulate GLP-1R expression in pancreatic cells 29,30,31

doi: 10.2174/1573399812666151223093841 230 BornerTShaulsonEDTinsleyICSteinLMHornCCHayesMRet al
