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A systematic review in The Aesthetic Surgery Journal highlighted that GLP-1 agonists cause morphological changes resembling advanced aging

a Model based estimates are based on an analysis of covariance (or logistic regression for the 5%, 10%, 15% or 20% achievement endpoints) including treatment as a factor and baseline value as a covariate

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Oral semaglutide also resulted in a greater mean reduction in weight from baseline when compared with liraglutide and placebo (estimated mean change from baseline of -1.6 kg, -1.1 kg, and -0.3 kg, respectively [ P = .0006 for oral semaglutide vs