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After a 36-week lead-in period with tirzepatide treatment, participants who continued on the compound for an additional 52 weeks achieved 25.8% total weight loss

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Weight loss itself also triggers metabolic adaptation

The result was striking as participants lost an average of roughly 15% of body weight in 68 weeks when semaglutide was combined with lifestyle support

Patients should follow regular checkups every 3 or 4 months , instead of every 6 months as usual, to detect any tooth caries, dental cleaning, and periodontal maintenance