semaglutide inventor Reflections on the discovery GLP-1 as a satiety hormone: Implications for obesity therapy and future directions The story of semaglutide

Novo Nordisks factories work nonstop turning out Ozempic and Wegovy, its blockbuster weight-loss drugs, but the Danish company has far bigger ambitions.

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Purpose Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have gained considerable media attention, but there is limited knowledge about those receiving the drugs

Aims/hypothesis Unimolecular peptides targeting the receptors for glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP) and glucagon (GCG) have been shown to improve glycaemic management in both mice and humans

The memory and focus problems common to depression, researchers hope, may be alleviated by GLP-1 drugs like Wegovy