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15 However, human evidence for weight loss remains inconsistent

Core muscle strength may not immediately adapt to changing body composition, potentially causing increased mechanical stress on the lumbar spine, though this mechanism remains hypothetical for pharmacologic weight loss

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GIP (glucose-dependent insulinotropic polypeptide) is another gut hormone that, like GLP-1, helps regulate blood sugar and appetite, so activating both pathways may provide additional benefits

10.1016/S2213-8587(22)00008-0 38 KakuK.RasmussenM