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In terms of HbA1c lowering, oral semaglutide 7 mg was comparable to liraglutide 0.9 mg, and oral semaglutide 14 mg was superior to liraglutide 0.9 mg in Japanese patients with T2D

Metabolic adaptation

Due to differences in their pharmacokinetic profiles, in this exploratory experiment, we applied a higher dose of the GLP1/E conjugate (100 nmol/kg), relative to those of the dual (GLP1/GIP) or triple (GLP1/GIP/Glucagon) agonists (10 nmol/kg)

As he says 'No similar treatment outcome had ever been seen before, and the significance of this result cannot be overstated

doi: 10.1016/j.brainres.2017.10.012 240 LiTJiaoJJHolscherCWuMNZhangJTongJQet al