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Cardiovascular Outcomes# EXSCEL Trial (Exenatide)# The EXSCEL trial (Holman et al., NEJM 2017) enrolled 14,752 patients with T2D (73.1% with prior CV disease): Primary MACE: HR 0.91 (95% CI 0.83-1.00, p=0.06 for superiority) Non-inferiority achieved

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Some people see a pound or two drop, while others see no change or even a slight temporary increase due to fluid shifts
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It should be avoided in patients with severe gastrointestinal disorders such as gastroparesis, as delayed gastric emptying may worsen symptoms[13]

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