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There are mounting reports on the effects of intestinal microbial metabolites on human health

The net effect depends entirely on your insurance situation

For example, liraglutide (LEADER trial), injectable semaglutide (SUSTAIN-6), dulaglutide (REWIND), and high-dose semaglutide (SELECT) have shown cardiovascular risk reduction in their respective clinical trials

To increase the plasma half-life by avoiding renal elimination, GLP-1 analogs were modified by adding acyl groups (liraglutide and semaglutide) or large molecules such as albumin (albiglutide) and the Fc portion of IgG (dulaglutide)

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In many cases the episode is self-limited