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Similar content being viewed by others Introduction Type 2 diabetes is a chronic, lifelong condition that can cause micro- and macro-vascular complications with increased morbidity and mortality associated with a deterioration of glycaemic control, placing significant burdens on patients and health care systems [1]

Beyond weight loss, retatrutide's glucagon receptor activity may theoretically offer advantages for women with metabolic dysfunction-associated steatotic liver disease (MASLD, previously termed non-alcoholic fatty liver disease or NAFLD) or its more severe form, metabolic dysfunction-associated steatohepatitis (MASH, previously NASH)

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Our current and previous findings in mice suggest that cell GLP-1R signaling promotes the secretion of a factor that can act on cells to turn on cell PCSK1 expression (24)