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Description
Exenatide, a 39-amino acid peptide, is the first GLP-1R agonists approved by the US FDA in 2005 and EMA in 2007

Ann Intern Med (1980) 92(5):6139

Even when it comes to trending medications like semaglutide

It has 94% structural similarity to the naturally occurring GLP-1 hormone, which is secreted by intestinal L-cells in response to food intake
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Understanding these pharmacogenomic determinants is essential for the development of precision medicine approaches, enabling more accurate prediction of treatment response and individualized therapy for patients with T2DM
