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Compared with SGLT2i alone, combination therapy was significantly associated with 42% lower risk of ischemic stroke, 37% lower risk of MI, 46% lower risk of 3-point MACE, and 45% lower risk of 5-point MACE among people with T2D and ASCVD

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In research models, semaglutide has been evaluated for its role in insulin secretion pathways, glucagon regulation, gastric emptying mechanisms, and central appetite signaling