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The following information was derived from each of the trials, including the publication details (clinical trial number and trial phase, source of funding, author, year of publication, country), participant profiles (age and BMI at baseline, percentage of female, ethnicity, comorbidity), treatment characteristics (sample size, placebo controlled, trial duration, dosage, with or without lifestyle intervention), and outcome measures

This shift in bile composition creates an environment where stone formation becomes more likely, particularly in the first 612 months of therapy

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Hydration, low-fat diet adherence, and regular follow-up help distinguish manageable GI effects from signals requiring dose adjustment or formulation change