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Skipping doses or taking extended breaks can reset the tolerance process, potentially causing reactions to return at previous intensity when you resume

The percentage of patients who experienced a greater than one-stage improvement in scarring, or fibrosis, without worsening of their disease was 54.9%, 51.3%, and 51.0% from the lowest to highest doses

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Each injection should be at least 2-3 centimeters away from the previous one

Nat Rev Cardiol 2018

In the SURMOUNT-1 and SURMOUNT-2 approval trials, around 5% of those treated reported hair loss, compared with roughly 1% on placebo
