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Dipeptidyl Peptidase 4 Inhibitors: Novel Therapeutic Agents in the Management of Type II Diabetes Mellitus

in which: liver GcgR KO mice achieve 02% of the IUB288-induced BW loss seen in WT, liver FGF21 KO achieve 50%, liver farnesoid X receptor KO 30%, and CNS -Klotho KO 60% [100], [127]

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At the 15 mg dose (highest): Participants lost an average of 22.5% of their starting body weight

While insulins and GLP-1RAs have been considered equally effective at reducing HbA 1c [41, 42], a more recent meta-analysis reported that long-acting, once-weekly GLP-1RAs (exenatide and dulaglutide) achieve significantly greater reductions in HbA 1c than basal insulins such as insulin detemir, insulin glargine and insulin degludec [43]

Ozempic is the most popular GLP-1 medication in the US, with the highest share of prescriptions in 2024