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Figure 7B shows the top 20 differentially regulated genes in these pathways, depicting liraglutide-mediated upregulation in the ARH and downregulation in the PVH and LS, while the expression profile for semaglutide more closely resembled weight-matched and vehicle controls

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For example, individuals who completed a 36-week course of tirzepatide regained nearly half their lost weight after switching to a placebo