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Mushroom extracts should be avoided by individuals with autoimmune conditions, those on immunosuppressive medications, and pregnant or breastfeeding women due to potential or unknown health risks, Phillips cautions

However, dopaminergic activity in other limbic structures can also interact with GLP-1 as, in addition to reducing lever pressing for sucrose, icv exendin-4 enhances dopamine turnover in the amygdala and these effects are partly inhibited by intra-amygdala infusion of a dopamine receptor type 2 antagonist [85]

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Limitations Meta-analyses review published literature to evaluate and quantitatively analyze the results of multiple studies in a comprehensive manner