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For a compound intended for chronic use, that gap in the data is the most important honest limitation to acknowledge

[DOI] [PubMed] [Google Scholar] de Toro-Martn J, Gunard F, Tchernof A, Hould F-S, Lebel S, Julien F, Marceau S & Vohl M-C (2019) Body mass index is associated with epigenetic age acceleration in the visceral adipose tissue of subjects with severe obesity

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Cancer survivors often face unique health challenges, including treatment-related metabolic complications such as weight gain, insulin resistance, and increased cardiovascular risk

In my view, a double-digit drop for a rigorous clinical trial in a notoriously difficult disease area feels like an overreaction

Missing two or more consecutive weeks resets your GLP-1 tolerance